Do I really need to take my medication every day? For your HIV treatment to be successful, you will probably need to take three different drugs, which affect HIV at different stages of its replication. HIV treatments are simpler to take than they used to be and there are options so you can find the combination that’s best for you. The three drugs might come in one or two tablets, making them easier to take. Once you go on treatment you must take it properly and regularly, this is called adherence. Missing even a few doses a month can mean your treatment doesn’t work as well as it could do, and your HIV may become resistant to those drugs. It’s important to follow your doctor’s instructions about taking your treatments and what to do if you forget to take it.