Can I stop taking my daily PrEP? If you are planning to stop having sex, you may wish to stop daily dosing PrEP. PrEP is very flexible if your circumstances change. Before you stop, cis men* should carry on taking PrEP for another two sex-free days. Everyone else should carry on taking PrEP for seven sex-free days. This includes when PrEP is being taken for vaginal/frontal protection. *Cis man refers to anyone who was assigned male at birth and who still identifies as a man.