Yes, but although PrEP is very flexible to change dosing - this is only for some people. It is also only if the PrEP you use is Tenofovir/emtricitabine(TDF/FTC).

Only cis men* who have sex with other men can safely change from daily dosing to Event Based PrEP. 

Everyone else, including for vaginal/frontal protection, can only use daily dosing. Event Based PrEP is not suitable. For more information on Event Based PrEP please see the PrEPster website:

Event based PrEP has not been studied using Descovy (TAF/FTC). If your current PrEP drug is Descovy, only daily dosing is recommended.

If you can use event-based PrEP, this involves:

  1. Taking a double dose 2 to 24 hours before sex.
  2. Taking a single pill every 24 hours, until you’ve had 2 sex free days.

For example, if you have sex once, this will involve a double dose before sex. Then a second pill after 24 and 48 hours. Total = 4 pills.

* Cis man refers to anyone who was assigned male at birth and who still identifies as a male.