Drug resistance Every time HIV reproduces there is a chance it can change in a way that means it is less susceptible to medication. This means the virus will continue to replicate and you may have to change your treatment. At your first specialist appointment, your blood should be tested for resistance, ensuring you’re given the most effective treatment. If you find you are resistant to a particular treatment, there are other treatment options. When you start treatment you will be started on more than one type of drug, although you may only take one tablet. Multi-drug use makes it harder for HIV to become resistant to one particular type. Ensuring that you always keep up to date with your medication by taking it at the correct times every day means your viral load will be as low as possible. This makes it more difficult for HIV to mutate and reproduce, and makes you significantly less infectious.